Names & Taxonomy
- Uniprot ID:
- P29275
- Entry Name:
- AA2BR_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosine receptor A2b
- Gene Names:
- ADORA2B
- Gene Names Primary:
- ADORA2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 332
- Sequence:
- MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
- Cross Reference Drug Bank:
- DB00640 DB04932 DB00824 DB00277
- Gene Ontology Go:
- integral component of plasma membrane
intracellular
plasma membrane
G-protein coupled adenosine receptor activity
activation of adenylate cyclase activity
activation of MAPK activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular defense response
cellular protein metabolic process
cellular response to extracellular stimulus
excretion
G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of chemokine production
positive regulation of chronic inflammatory response to non-antigenic stimulus
positive regulation of guanylate cyclase activity
positive regulation of interleukin-6 production
positive regulation of mast cell degranulation
positive regulation of vascular endothelial growth factor production
relaxation of vascular smooth muscle - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
activation of MAPK activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular defense response
cellular protein metabolic process
cellular response to extracellular stimulus
excretion
G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of chemokine production
positive regulation of chronic inflammatory response to non-antigenic stimulus
positive regulation of guanylate cyclase activity
positive regulation of interleukin-6 production
positive regulation of mast cell degranulation
positive regulation of vascular endothelial growth factor production
relaxation of vascular smooth muscle - Gene Ontology Molecular Function:
- G-protein coupled adenosine receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix