Names & Taxonomy
- Uniprot ID:
- P27144
- Entry Name:
- KAD4_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)
- Gene Names:
- AK4 AK3 AK3L1
- Gene Names Primary:
- AK4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 223
- Sequence:
- MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
- Catalytic Activity:
- NTP + AMP = NDP + ADP.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5.3 uM for AMP with ATP as phosphate donor
- Cross Reference Drug Bank:
- DB00718 DB00300
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
mitochondrion
adenylate kinase activity
ATP binding
GTP binding
nucleoside diphosphate kinase activity
nucleoside triphosphate adenylate kinase activity
ADP biosynthetic process
AMP metabolic process
ATP metabolic process
brain development
GTP metabolic process
liver development
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
response to drug
small molecule metabolic process - Gene Ontology Biological Process:
- ADP biosynthetic process
AMP metabolic process
ATP metabolic process
brain development
GTP metabolic process
liver development
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
response to drug
small molecule metabolic process - Gene Ontology Molecular Function:
- adenylate kinase activity
ATP binding
GTP binding
nucleoside diphosphate kinase activity
nucleoside triphosphate adenylate kinase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
GTP-binding
Kinase
Mitochondrion
Nucleotide-binding
Reference proteome
Transferase