Names & Taxonomy
- Uniprot ID:
- P22888
- Entry Name:
- LSHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)
- Gene Names:
- LHCGR LCGR LGR2 LHRHR
- Gene Names Primary:
- LHCGR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 699
- Sequence:
- MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
- Cross Reference Drug Bank:
- DB06719 DB00050 DB00097 DB00014 DB00044 DB00032
- Gene Ontology Go:
- endosome
integral component of plasma membrane
plasma membrane
choriogonadotropin hormone binding
choriogonadotropin hormone receptor activity
G-protein coupled peptide receptor activity
luteinizing hormone receptor activity
activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular response to gonadotropin stimulus
cognition
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hormone-mediated signaling pathway
luteinizing hormone signaling pathway
male genitalia development
male gonad development
ovulation cycle process
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cAMP-mediated signaling
positive regulation of inositol trisphosphate biosynthetic process - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular response to gonadotropin stimulus
cognition
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hormone-mediated signaling pathway
luteinizing hormone signaling pathway
male genitalia development
male gonad development
ovulation cycle process
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cAMP-mediated signaling
positive regulation of inositol trisphosphate biosynthetic process - Gene Ontology Molecular Function:
- choriogonadotropin hormone binding
choriogonadotropin hormone receptor activity
G-protein coupled peptide receptor activity
luteinizing hormone receptor activity - Gene Ontology Cellular Component:
- endosome
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Leucine-rich repeat
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transducer
Transmembrane
Transmembrane helix