Names & Taxonomy
- Uniprot ID:
- P22694
- Entry Name:
- KAPCB_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
- Gene Names:
- PRKACB
- Gene Names Primary:
- PRKACB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by cAMP.
- Active Site:
- ACT_SITE 167 167 Proton acceptor.
- Gene Ontology Go:
- cAMP-dependent protein kinase complex
centrosome
ciliary base
cytosol
extracellular exosome
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
ATP binding
cAMP-dependent protein kinase activity
magnesium ion binding
ubiquitin protein ligase binding
activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
blood coagulation
carbohydrate metabolic process
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
gluconeogenesis
glucose metabolic process
innate immune response
intracellular signal transduction
negative regulation of meiotic cell cycle
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
neural tube closure
neurotrophin TRK receptor signaling pathway
protein phosphorylation
regulation of insulin secretion
regulation of protein processing
renal water homeostasis
response to clozapine
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
synaptic transmission
transmembrane transport
triglyceride catabolic process
water transport - Gene Ontology Biological Process:
- activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
blood coagulation
carbohydrate metabolic process
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
gluconeogenesis
glucose metabolic process
innate immune response
intracellular signal transduction
negative regulation of meiotic cell cycle
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
neural tube closure
neurotrophin TRK receptor signaling pathway
protein phosphorylation
regulation of insulin secretion
regulation of protein processing
renal water homeostasis
response to clozapine
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
synaptic transmission
transmembrane transport
triglyceride catabolic process
water transport - Gene Ontology Molecular Function:
- ATP binding
cAMP-dependent protein kinase activity
magnesium ion binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cAMP-dependent protein kinase complex
centrosome
ciliary base
cytosol
extracellular exosome
nucleoplasm
perinuclear region of cytoplasm
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Kinase
Lipoprotein
Membrane
Myristate
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
cAMP - Interacts With:
- Q92624; Q92917; P08238