Names & Taxonomy
- Uniprot ID:
- P22001
- Entry Name:
- KCNA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3)
- Gene Names:
- KCNA3 HGK5
- Gene Names Primary:
- KCNA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 575
- Sequence:
- MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- axon
membrane raft
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
outward rectifier potassium channel activity
voltage-gated ion channel activity
potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Biological Process:
- potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
outward rectifier potassium channel activity
voltage-gated ion channel activity - Gene Ontology Cellular Component:
- axon
membrane raft
plasma membrane
voltage-gated potassium channel complex - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel