Names & Taxonomy
- Uniprot ID:
- P13497
- Entry Name:
- BMP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
- Gene Names:
- BMP1 PCOLC
- Gene Names Primary:
- BMP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 986
- Sequence:
- MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, trans-Golgi network
Function
- Function:
- Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
- Catalytic Activity:
- Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Activity is increased by the procollagen C-endopeptidase enhancer protein.
- Active Site:
- ACT_SITE 214 214
- Gene Ontology Go:
- extracellular region
extracellular space
Golgi apparatus
membrane-bounded vesicle
proteinaceous extracellular matrix
calcium ion binding
cytokine activity
metalloendopeptidase activity
metallopeptidase activity
peptidase activity
transforming growth factor beta receptor binding
zinc ion binding
BMP signaling pathway
cartilage condensation
cell development
extracellular matrix disassembly
extracellular matrix organization
lipoprotein metabolic process
multicellular organism development
ossification
positive regulation of cartilage development
positive regulation of pathway-restricted SMAD protein phosphorylation
proteolysis
regulation of apoptotic process
regulation of MAPK cascade
skeletal system development
SMAD protein signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- BMP signaling pathway
cartilage condensation
cell development
extracellular matrix disassembly
extracellular matrix organization
lipoprotein metabolic process
multicellular organism development
ossification
positive regulation of cartilage development
positive regulation of pathway-restricted SMAD protein phosphorylation
proteolysis
regulation of apoptotic process
regulation of MAPK cascade
skeletal system development
SMAD protein signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
cytokine activity
metalloendopeptidase activity
metallopeptidase activity
peptidase activity
transforming growth factor beta receptor binding
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
Golgi apparatus
membrane-bounded vesicle
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Alternative splicing
Calcium
Chondrogenesis
Cleavage on pair of basic residues
Complete proteome
Cytokine
Developmental protein
Differentiation
Disease mutation
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Golgi apparatus
Growth factor
Hydrolase
Metal-binding
Metalloprotease
Osteogenesis
Osteogenesis imperfecta
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen - Interacts With:
- O14793