Names & Taxonomy
- Uniprot ID:
- P10912
- Entry Name:
- GHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
- Gene Names:
- GHR
- Gene Names Primary:
- GHR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 638
- Sequence:
- MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.
Function
- Function:
- Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).
- Cross Reference Drug Bank:
- DB00082 DB00052
- Gene Ontology Go:
- cell surface
extracellular region
extracellular space
growth hormone receptor complex
integral component of membrane
integral component of plasma membrane
intracellular
plasma membrane
receptor complex
cytokine receptor activity
growth factor binding
peptide hormone binding
proline-rich region binding
protein homodimerization activity
protein kinase binding
2-oxoglutarate metabolic process
activation of JAK2 kinase activity
activation of MAPK activity
allantoin metabolic process
cellular response to hormone stimulus
citrate metabolic process
creatine metabolic process
creatinine metabolic process
endocytosis
fatty acid metabolic process
growth hormone receptor signaling pathway
insulin-like growth factor receptor signaling pathway
isoleucine metabolic process
JAK-STAT cascade
JAK-STAT cascade involved in growth hormone signaling pathway
multicellular organism metabolic process
oxaloacetate metabolic process
positive regulation of multicellular organism growth
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
receptor internalization
regulation of multicellular organism growth
response to cycloheximide
response to estradiol
succinate metabolic process
taurine metabolic process
valine metabolic process - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
activation of JAK2 kinase activity
activation of MAPK activity
allantoin metabolic process
cellular response to hormone stimulus
citrate metabolic process
creatine metabolic process
creatinine metabolic process
endocytosis
fatty acid metabolic process
growth hormone receptor signaling pathway
insulin-like growth factor receptor signaling pathway
isoleucine metabolic process
JAK-STAT cascade
JAK-STAT cascade involved in growth hormone signaling pathway
multicellular organism metabolic process
oxaloacetate metabolic process
positive regulation of multicellular organism growth
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
receptor internalization
regulation of multicellular organism growth
response to cycloheximide
response to estradiol
succinate metabolic process
taurine metabolic process
valine metabolic process - Gene Ontology Molecular Function:
- cytokine receptor activity
growth factor binding
peptide hormone binding
proline-rich region binding
protein homodimerization activity
protein kinase binding - Gene Ontology Cellular Component:
- cell surface
extracellular region
extracellular space
growth hormone receptor complex
integral component of membrane
integral component of plasma membrane
intracellular
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Dwarfism
Endocytosis
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Q16829; P01241; P16333; Q9JLI4; P18031; P17706; P26045; P43378; P23467; Q9HD43; Q12913