Names & Taxonomy
- Uniprot ID:
- P08254
- Entry Name:
- MMP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
- Gene Names:
- MMP3 STMY1
- Gene Names Primary:
- MMP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 477
- Sequence:
- MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
- Catalytic Activity:
- Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 4 Ca(2+) ions per subunit.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
- Active Site:
- ACT_SITE 219 219
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
endopeptidase activity
metalloendopeptidase activity
zinc ion binding
cellular response to nitric oxide
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
negative regulation of hydrogen peroxide metabolic process
positive regulation of oxidative stress-induced cell death
positive regulation of protein oligomerization
proteolysis - Gene Ontology Biological Process:
- cellular response to nitric oxide
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
negative regulation of hydrogen peroxide metabolic process
positive regulation of oxidative stress-induced cell death
positive regulation of protein oligomerization
proteolysis - Gene Ontology Molecular Function:
- calcium ion binding
endopeptidase activity
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen - Interacts With:
- A4D127