Names & Taxonomy
- Uniprot ID:
- P07954
- Entry Name:
- FUMH_HUMAN
- Status:
- reviewed
- Protein Names:
- Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)
- Gene Names:
- FH
- Gene Names Primary:
- FH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 510
- Sequence:
- MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic: Cytoplasm.
Function
- Function:
- Also acts as a tumor suppressor.
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
- Catalytic Activity:
- (S)-malate = fumarate + H(2)O.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrial matrix
mitochondrion
tricarboxylic acid cycle enzyme complex
fumarate hydratase activity
cellular metabolic process
fumarate metabolic process
homeostasis of number of cells within a tissue
malate metabolic process
protein tetramerization
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular metabolic process
fumarate metabolic process
homeostasis of number of cells within a tissue
malate metabolic process
protein tetramerization
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- fumarate hydratase activity
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrial matrix
mitochondrion
tricarboxylic acid cycle enzyme complex - Keywords:
- 3D-structure
Acetylation
Alternative initiation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Lyase
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle
Tumor suppressor - Interacts With:
- P11309