Names & Taxonomy
- Uniprot ID:
- P07477
- Entry Name:
- TRY1_HUMAN
- Status:
- reviewed
- Protein Names:
- Trypsin-1 (EC 3.4.21.4) (Beta-trypsin) (Cationic trypsinogen) (Serine protease 1) (Trypsin I) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]
- Gene Names:
- PRSS1 TRP1 TRY1 TRYP1
- Gene Names Primary:
- PRSS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 247
- Sequence:
- MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
- Catalytic Activity:
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
- Active Site:
- ACT_SITE 63 63 Charge relay system.; ACT_SITE 107 107 Charge relay system.; ACT_SITE 200 200 Charge relay system.
- Cross Reference Drug Bank:
- DB06692
- Gene Ontology Go:
- blood microparticle
extracellular exosome
extracellular region
metal ion binding
serine-type endopeptidase activity
cobalamin metabolic process
digestion
extracellular matrix disassembly
extracellular matrix organization
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cobalamin metabolic process
digestion
extracellular matrix disassembly
extracellular matrix organization
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- metal ion binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- blood microparticle
extracellular exosome
extracellular region - Keywords:
- 3D-structure
Calcium
Complete proteome
Digestion
Direct protein sequencing
Disease mutation
Disulfide bond
Hydrolase
Metal-binding
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen