Names & Taxonomy
- Uniprot ID:
- P04179
- Entry Name:
- SODM_HUMAN
- Status:
- reviewed
- Protein Names:
- Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)
- Gene Names:
- SOD2
- Gene Names Primary:
- SOD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 222
- Sequence:
- MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
- Catalytic Activity:
- 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; ; Note=Binds 1 Mn(2+) ion per subunit.;
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
mitochondrion
identical protein binding
manganese ion binding
superoxide dismutase activity
age-dependent response to reactive oxygen species
negative regulation of cell proliferation
negative regulation of neuron apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
oxygen homeostasis
protein homotetramerization
regulation of blood pressure
regulation of transcription from RNA polymerase II promoter
release of cytochrome c from mitochondria
removal of superoxide radicals
response to reactive oxygen species
response to superoxide
superoxide metabolic process
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure - Gene Ontology Biological Process:
- age-dependent response to reactive oxygen species
negative regulation of cell proliferation
negative regulation of neuron apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
oxygen homeostasis
protein homotetramerization
regulation of blood pressure
regulation of transcription from RNA polymerase II promoter
release of cytochrome c from mitochondria
removal of superoxide radicals
response to reactive oxygen species
response to superoxide
superoxide metabolic process
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure - Gene Ontology Molecular Function:
- identical protein binding
manganese ion binding
superoxide dismutase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Manganese
Metal-binding
Mitochondrion
Nitration
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide - Interacts With:
- Itself