Names & Taxonomy
- Uniprot ID:
- P04083
- Entry Name:
- ANXA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)
- Gene Names:
- ANXA1 ANX1 LPC1
- Gene Names Primary:
- ANXA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 346
- Sequence:
- MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
- Cross Reference Drug Bank:
- DB00288 DB01234 DB00741
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
cell surface
cornified envelope
cytoplasm
cytoplasmic vesicle membrane
early endosome membrane
endosome
extracellular exosome
extracellular region
extracellular space
extrinsic component of endosome membrane
extrinsic component of external side of plasma membrane
extrinsic component of membrane
focal adhesion
lateral plasma membrane
mast cell granule
mitochondrial membrane
motile cilium
nucleoplasm
nucleus
phagocytic cup
plasma membrane
protein complex
sarcolemma
vesicle
annealing helicase activity
calcium ion binding
calcium-dependent phospholipid binding
calcium-dependent protein binding
double-stranded DNA-dependent ATPase activity
helicase activity
phospholipase A2 inhibitor activity
phospholipid binding
protein binding, bridging
receptor binding
single-stranded DNA binding
single-stranded RNA binding
structural molecule activity
actin cytoskeleton reorganization
adaptive immune response
alpha-beta T cell differentiation
arachidonic acid secretion
cell surface receptor signaling pathway
cellular response to glucocorticoid stimulus
cellular response to hydrogen peroxide
DNA duplex unwinding
DNA rewinding
endocrine pancreas development
estrous cycle
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
gliogenesis
granulocyte chemotaxis
hepatocyte differentiation
inflammatory response
innate immune response
insulin secretion
keratinocyte differentiation
monocyte chemotaxis
muscle contraction
myoblast migration involved in skeletal muscle regeneration
negative regulation of apoptotic process
negative regulation of exocytosis
negative regulation of interleukin-8 secretion
negative regulation of phospholipase A2 activity
negative regulation of T-helper 2 cell differentiation
neutrophil clearance
neutrophil homeostasis
peptide cross-linking
phagocytosis
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of interleukin-2 production
positive regulation of neutrophil apoptotic process
positive regulation of prostaglandin biosynthetic process
positive regulation of T cell proliferation
positive regulation of T-helper 1 cell differentiation
positive regulation of vesicle fusion
positive regulation of wound healing
prolactin secretion
prostate gland development
regulation of cell shape
regulation of hormone secretion
regulation of inflammatory response
regulation of interleukin-1 production
regulation of leukocyte migration
response to drug
response to estradiol
response to interleukin-1
response to peptide hormone
response to X-ray
signal transduction - Gene Ontology Biological Process:
- actin cytoskeleton reorganization
adaptive immune response
alpha-beta T cell differentiation
arachidonic acid secretion
cell surface receptor signaling pathway
cellular response to glucocorticoid stimulus
cellular response to hydrogen peroxide
DNA duplex unwinding
DNA rewinding
endocrine pancreas development
estrous cycle
gliogenesis
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
granulocyte chemotaxis
hepatocyte differentiation
inflammatory response
innate immune response
insulin secretion
keratinocyte differentiation
monocyte chemotaxis
muscle contraction
myoblast migration involved in skeletal muscle regeneration
negative regulation of apoptotic process
negative regulation of exocytosis
negative regulation of interleukin-8 secretion
negative regulation of phospholipase A2 activity
negative regulation of T-helper 2 cell differentiation
neutrophil clearance
neutrophil homeostasis
peptide cross-linking
phagocytosis
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of interleukin-2 production
positive regulation of neutrophil apoptotic process
positive regulation of prostaglandin biosynthetic process
positive regulation of T cell proliferation
positive regulation of T-helper 1 cell differentiation
positive regulation of vesicle fusion
positive regulation of wound healing
prolactin secretion
prostate gland development
regulation of cell shape
regulation of hormone secretion
regulation of inflammatory response
regulation of interleukin-1 production
regulation of leukocyte migration
response to drug
response to estradiol
response to interleukin-1
response to peptide hormone
response to X-ray
signal transduction - Gene Ontology Molecular Function:
- annealing helicase activity
calcium-dependent phospholipid binding
calcium-dependent protein binding
calcium ion binding
double-stranded DNA-dependent ATPase activity
helicase activity
phospholipase A2 inhibitor activity
phospholipid binding
protein binding, bridging
receptor binding
single-stranded DNA binding
single-stranded RNA binding
structural molecule activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
cell surface
cornified envelope
cytoplasm
cytoplasmic vesicle membrane
early endosome membrane
endosome
extracellular exosome
extracellular region
extracellular space
extrinsic component of endosome membrane
extrinsic component of external side of plasma membrane
extrinsic component of membrane
focal adhesion
lateral plasma membrane
mast cell granule
mitochondrial membrane
motile cilium
nucleoplasm
nucleus
phagocytic cup
plasma membrane
protein complex
sarcolemma
vesicle - Keywords:
- 3D-structure
Acetylation
Adaptive immunity
Annexin
Calcium
Calcium/phospholipid-binding
Cell membrane
Cell projection
Cilium
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endosome
Immunity
Inflammatory response
Innate immunity
Isopeptide bond
Membrane
Metal-binding
Nucleus
Pharmaceutical
Phospholipase A2 inhibitor
Phosphoprotein
Reference proteome
Repeat
Secreted
Ubl conjugation - Interacts With:
- Q9Y6K9; Q13546