Names & Taxonomy
- Uniprot ID:
- P00387
- Entry Name:
- NB5R3_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) [Cleaved into: NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form]
- Gene Names:
- CYB5R3 DIA1
- Gene Names Primary:
- CYB5R3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 301
- Sequence:
- MGAQLSTLGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side.; Isoform 2: Cytoplasm. Note=Produces the soluble form found in erythrocytes.
Function
- Function:
- Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
- Catalytic Activity:
- NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- cytoplasm
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
hemoglobin complex
lipid particle
membrane
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion
ADP binding
AMP binding
cytochrome-b5 reductase activity, acting on NAD(P)H
FAD binding
flavin adenine dinucleotide binding
NAD binding
blood circulation
cholesterol biosynthetic process
L-ascorbic acid metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- blood circulation
cholesterol biosynthetic process
L-ascorbic acid metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ADP binding
AMP binding
cytochrome-b5 reductase activity, acting on NAD(P)H
FAD binding
flavin adenine dinucleotide binding
NAD binding - Gene Ontology Cellular Component:
- cytoplasm
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
hemoglobin complex
lipid particle
membrane
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
FAD
Flavoprotein
Lipid biosynthesis
Lipid metabolism
Lipoprotein
Membrane
Mitochondrion
Mitochondrion outer membrane
Myristate
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism