Names & Taxonomy
- Uniprot ID:
- O95644
- Entry Name:
- NFAC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)
- Gene Names:
- NFATC1 NFAT2 NFATC
- Gene Names Primary:
- NFATC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 943
- Sequence:
- MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).
- Cross Reference Drug Bank:
- DB00852
- Gene Ontology Go:
- cytoplasm
cytosol
nuclear chromatin
nucleoplasm
nucleus
FK506 binding
mitogen-activated protein kinase p38 binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
calcineurin-NFAT signaling cascade
Fc-epsilon receptor signaling pathway
innate immune response
intracellular signal transduction
negative regulation of Wnt signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
stimulatory C-type lectin receptor signaling pathway
transcription from RNA polymerase II promoter - Gene Ontology Biological Process:
- calcineurin-NFAT signaling cascade
Fc-epsilon receptor signaling pathway
innate immune response
intracellular signal transduction
negative regulation of Wnt signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
stimulatory C-type lectin receptor signaling pathway
transcription from RNA polymerase II promoter - Gene Ontology Molecular Function:
- FK506 binding
mitogen-activated protein kinase p38 binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nuclear chromatin
nucleoplasm
nucleus - Keywords:
- 3D-structure
Activator
Alternative initiation
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation - Interacts With:
- P18846; P15336; P18847; P16220; P31276; P05412; O15294