Names & Taxonomy
- Uniprot ID:
- O75027
- Entry Name:
- ABCB7_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family B member 7, mitochondrial (ATP-binding cassette transporter 7) (ABC transporter 7 protein)
- Gene Names:
- ABCB7 ABC7
- Gene Names Primary:
- ABCB7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 752
- Sequence:
- MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIPESLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
ATP binding
ATPase activity, coupled to transmembrane movement of substances
heme transporter activity
cellular iron ion homeostasis
heme transport
small molecule metabolic process
transmembrane transport
transport - Gene Ontology Biological Process:
- cellular iron ion homeostasis
heme transport
small molecule metabolic process
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATPase activity, coupled to transmembrane movement of substances
ATP binding
heme transporter activity - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
mitochondrion - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix
Transport