Names & Taxonomy
- Uniprot ID:
- O60911
- Entry Name:
- CATL2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V)
- Gene Names:
- CTSV CATL2 CTSL2 CTSU UNQ268/PRO305
- Gene Names Orf:
- UNQ268/PRO305
- Gene Names Primary:
- CTSV
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 334
- Sequence:
- MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome
Function
- Function:
- Cysteine protease. May have an important role in corneal physiology.
- Catalytic Activity:
- The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
- Active Site:
- ACT_SITE 138 138
- Gene Ontology Go:
- apical part of cell
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
microvillus
neuron projection
nucleolus
perikaryon
secretory granule
aminopeptidase activity
cysteine-type carboxypeptidase activity
cysteine-type endopeptidase activity
cysteine-type peptidase activity
peptide binding
antigen processing and presentation of exogenous peptide antigen via MHC class II
autophagic cell death
cellular response to starvation
decidualization
extracellular matrix disassembly
extracellular matrix organization
hair follicle morphogenesis
multicellular organism aging
negative regulation of keratinocyte proliferation
nerve development
protein autoprocessing
proteolysis involved in cellular protein catabolic process
regulation of actin cytoskeleton reorganization
response to glucocorticoid
response to glucose
response to gonadotropin
Sertoli cell differentiation
spermatogenesis - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
autophagic cell death
cellular response to starvation
decidualization
extracellular matrix disassembly
extracellular matrix organization
hair follicle morphogenesis
multicellular organism aging
negative regulation of keratinocyte proliferation
nerve development
protein autoprocessing
proteolysis involved in cellular protein catabolic process
regulation of actin cytoskeleton reorganization
response to glucocorticoid
response to glucose
response to gonadotropin
Sertoli cell differentiation
spermatogenesis - Gene Ontology Molecular Function:
- aminopeptidase activity
cysteine-type carboxypeptidase activity
cysteine-type endopeptidase activity
cysteine-type peptidase activity
peptide binding - Gene Ontology Cellular Component:
- apical part of cell
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
lysosome
microvillus
neuron projection
nucleolus
perikaryon
secretory granule - Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Protease
Reference proteome
Signal
Thiol protease
Zymogen