Names & Taxonomy
- Uniprot ID:
- O60706
- Entry Name:
- ABCC9_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2)
- Gene Names:
- ABCC9 SUR2
- Gene Names Primary:
- ABCC9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1549
- Sequence:
- MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
- Cross Reference Drug Bank:
- DB00171 DB01016
- Gene Ontology Go:
- ATP-sensitive potassium channel complex
plasma membrane
sarcolemma
sarcomere
voltage-gated potassium channel complex
ATP binding
ATPase activity, coupled to transmembrane movement of substances
ion channel binding
potassium channel activity
potassium channel regulator activity
sulfonylurea receptor activity
transporter activity
cardiac conduction
defense response to virus
potassium ion import
potassium ion transport
regulation of cardiac conduction
signal transduction
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- cardiac conduction
defense response to virus
potassium ion import
potassium ion transport
regulation of cardiac conduction
signal transduction
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- ATPase activity, coupled to transmembrane movement of substances
ATP binding
ion channel binding
potassium channel activity
potassium channel regulator activity
sulfonylurea receptor activity
transporter activity - Gene Ontology Cellular Component:
- ATP-sensitive potassium channel complex
plasma membrane
sarcolemma
sarcomere
voltage-gated potassium channel complex - Keywords:
- ATP-binding
Alternative splicing
Atrial fibrillation
Cardiomyopathy
Complete proteome
Disease mutation
Glycoprotein
Membrane
Nucleotide-binding
Polymorphism
Receptor
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport