Names & Taxonomy
- Uniprot ID:
- O43272
- Entry Name:
- PROD_HUMAN
- Status:
- reviewed
- Protein Names:
- Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase) (Proline oxidase 2) (p53-induced gene 6 protein)
- Gene Names:
- PRODH PIG6 POX2
- Gene Names Primary:
- PRODH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 600
- Sequence:
- MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQEAYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQYQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDWFTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRMLQRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAYDNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQAGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Converts proline to delta-1-pyrroline-5-carboxylate.
- Pathway:
- Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
- Catalytic Activity:
- L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB06756 DB00172
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrial matrix
FAD binding
proline dehydrogenase activity
4-hydroxyproline catabolic process
cellular nitrogen compound metabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
positive regulation of cell death
proline catabolic process
proline catabolic process to glutamate
proline metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- 4-hydroxyproline catabolic process
cellular nitrogen compound metabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
positive regulation of cell death
proline catabolic process
proline catabolic process to glutamate
proline metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- FAD binding
proline dehydrogenase activity - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrial matrix - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Disease mutation
FAD
Flavoprotein
Mitochondrion
Oxidoreductase
Polymorphism
Proline metabolism
Reference proteome
Schizophrenia
Transit peptide