Names & Taxonomy
- Uniprot ID:
- O15144
- Entry Name:
- ARPC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
- Gene Names:
- ARPC2 ARC34 PRO2446
- Gene Names Orf:
- PRO2446
- Gene Names Primary:
- ARPC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 300
- Sequence:
- MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
- Gene Ontology Go:
- actin cytoskeleton
Arp2/3 protein complex
cell leading edge
cytoplasm
cytosol
endosome
extracellular exosome
focal adhesion
Golgi apparatus
muscle cell projection membrane
neuron projection
synapse
structural constituent of cytoskeleton
Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
movement of cell or subcellular component
positive regulation of lamellipodium assembly
positive regulation of substrate adhesion-dependent cell spreading
small GTPase mediated signal transduction - Gene Ontology Biological Process:
- Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
movement of cell or subcellular component
positive regulation of lamellipodium assembly
positive regulation of substrate adhesion-dependent cell spreading
small GTPase mediated signal transduction - Gene Ontology Molecular Function:
- structural constituent of cytoskeleton
- Gene Ontology Cellular Component:
- actin cytoskeleton
Arp2/3 protein complex
cell leading edge
cytoplasm
cytosol
endosome
extracellular exosome
focal adhesion
Golgi apparatus
muscle cell projection membrane
neuron projection
synapse - Keywords:
- Acetylation
Actin-binding
Cell junction
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Reference proteome
Synapse
Synaptosome - Interacts With:
- Q9BR76; P18206