Names & Taxonomy
- Uniprot ID:
- O00204
- Entry Name:
- ST2B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sulfotransferase family cytosolic 2B member 1 (ST2B1) (Sulfotransferase 2B1) (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2)
- Gene Names:
- SULT2B1 HSST2
- Gene Names Primary:
- SULT2B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 365
- Sequence:
- MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.
Function
- Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
- Catalytic Activity:
- 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1 mM MgCl2)
- Active Site:
- ACT_SITE 125 125 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
intracellular membrane-bounded organelle
nucleus
alcohol sulfotransferase activity
steroid sulfotransferase activity
3'-phosphoadenosine 5'-phosphosulfate metabolic process
small molecule metabolic process
steroid metabolic process
sulfate assimilation
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
small molecule metabolic process
steroid metabolic process
sulfate assimilation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- alcohol sulfotransferase activity
steroid sulfotransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
intracellular membrane-bounded organelle
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Lipid metabolism
Microsome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Steroid metabolism
Transferase - Interacts With:
- P14621; Q96Q35; O43900; P50225; O43704