Names & Taxonomy
- Uniprot ID:
- E7ENE0
- Entry Name:
- E7ENE0_HUMAN
- Status:
- unreviewed
- Protein Names:
- Extracellular calcium-sensing receptor
- Gene Names:
- CASR
- Gene Names Primary:
- CASR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1088
- Sequence:
- MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTFVLSVLQVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Gene Ontology Go:
- apical plasma membrane
axon terminus
basolateral plasma membrane
cell surface
cytoplasm
integral component of membrane
neuronal cell body
nucleus
calcium ion binding
drug binding
G-protein coupled receptor activity
magnesium ion binding
polyamine binding
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
apoptotic process
branching morphogenesis of an epithelial tube
calcium ion transport
cellular calcium ion homeostasis
cellular response to glucose stimulus
cellular response to hepatocyte growth factor stimulus
cellular response to hypoxia
cellular response to low-density lipoprotein particle stimulus
cellular response to peptide
cellular response to vitamin D
fat pad development
JNK cascade
ossification
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of ATPase activity
positive regulation of calcium ion import
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of insulin secretion
positive regulation of positive chemotaxis
positive regulation of vasoconstriction
response to calcium ion
response to fibroblast growth factor
response to ischemia
vasodilation - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
apoptotic process
branching morphogenesis of an epithelial tube
calcium ion transport
cellular calcium ion homeostasis
cellular response to glucose stimulus
cellular response to hepatocyte growth factor stimulus
cellular response to hypoxia
cellular response to low-density lipoprotein particle stimulus
cellular response to peptide
cellular response to vitamin D
fat pad development
JNK cascade
ossification
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of ATPase activity
positive regulation of calcium ion import
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of insulin secretion
positive regulation of positive chemotaxis
positive regulation of vasoconstriction
response to calcium ion
response to fibroblast growth factor
response to ischemia
vasodilation - Gene Ontology Molecular Function:
- calcium ion binding
drug binding
G-protein coupled receptor activity
magnesium ion binding
polyamine binding - Gene Ontology Cellular Component:
- apical plasma membrane
axon terminus
basolateral plasma membrane
cell surface
cytoplasm
integral component of membrane
neuronal cell body
nucleus - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Membrane
Proteomics identification
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 16641997