Names & Taxonomy

Uniprot ID:
A0A024RE06
Entry Name:
A0A024RE06_HUMAN
Status:
unreviewed
Protein Names:
DNA ligase (EC 6.5.1.1)
Gene Names:
LIG4 hCG_27194
Gene Names Orf:
hCG_27194
Gene Names Primary:
LIG4
Organism:
Homo sapiens (Human)

Structure

Length:
911
Sequence:
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI

Function

Catalytic Activity:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
Gene Ontology Go:
cytoplasm
DNA-dependent protein kinase-DNA ligase 4 complex
focal adhesion
nucleoplasm
plasma membrane
ATP binding
DNA binding
DNA ligase (ATP) activity
cell proliferation
cellular response to lithium ion
central nervous system development
chromosome organization
DNA biosynthetic process
DNA ligation involved in DNA recombination
DNA ligation involved in DNA repair
DNA replication
double-strand break repair via nonhomologous end joining
immunoglobulin V(D)J recombination
in utero embryonic development
isotype switching
negative regulation of neuron apoptotic process
neuron apoptotic process
positive regulation of fibroblast proliferation
positive regulation of neurogenesis
pro-B cell differentiation
response to gamma radiation
somatic stem cell population maintenance
T cell differentiation in thymus
T cell receptor V(D)J recombination
Gene Ontology Biological Process:
cell proliferation
cellular response to lithium ion
central nervous system development
chromosome organization
DNA biosynthetic process
DNA ligation involved in DNA recombination
DNA ligation involved in DNA repair
DNA replication
double-strand break repair via nonhomologous end joining
immunoglobulin V(D)J recombination
in utero embryonic development
isotype switching
negative regulation of neuron apoptotic process
neuron apoptotic process
positive regulation of fibroblast proliferation
positive regulation of neurogenesis
pro-B cell differentiation
response to gamma radiation
somatic stem cell population maintenance
T cell differentiation in thymus
T cell receptor V(D)J recombination
Gene Ontology Molecular Function:
ATP binding
DNA binding
DNA ligase (ATP) activity
Gene Ontology Cellular Component:
cytoplasm
DNA-dependent protein kinase-DNA ligase 4 complex
focal adhesion
nucleoplasm
plasma membrane
Keywords:
ATP-binding
DNA damage
DNA recombination
DNA repair
DNA replication
Ligase
Nucleotide-binding

Publication

PubMed ID:
11181995