Names & Taxonomy
- Uniprot ID:
- D2CGD1
- Entry Name:
- D2CGD1_HUMAN
- Status:
- unreviewed
- Protein Names:
- Fibroblast growth factor receptor (EC 2.7.10.1)
- Gene Names:
- FGFR2
- Gene Names Primary:
- FGFR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 732
- Sequence:
- MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
- Proteomes:
- UP000005640
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 537 537 Proton acceptor.
- Gene Ontology Go:
- integral component of membrane
intracellular membrane-bounded organelle
nucleoplasm
ATP binding
fibroblast growth factor-activated receptor activity
positive regulation of cell proliferation - Gene Ontology Biological Process:
- positive regulation of cell proliferation
- Gene Ontology Molecular Function:
- ATP binding
fibroblast growth factor-activated receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
intracellular membrane-bounded organelle
nucleoplasm - Keywords:
- ATP-binding
Complete proteome
Disulfide bond
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase