Names & Taxonomy

Uniprot ID:
A0A024R713
Entry Name:
A0A024R713_HUMAN
Status:
unreviewed
Protein Names:
Dihydrolipoyl dehydrogenase (EC 1.8.1.4)
Gene Names:
DLD hCG_17110
Gene Names Orf:
hCG_17110
Gene Names Primary:
DLD
Organism:
Homo sapiens (Human)

Structure

Length:
509
Sequence:
MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF

Function

Catalytic Activity:
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
Cofactor:
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
Gene Ontology Go:
acrosomal matrix
cilium
mitochondrion
myelin sheath
nucleoplasm
oxoglutarate dehydrogenase complex
pyruvate dehydrogenase complex
dihydrolipoyl dehydrogenase activity
flavin adenine dinucleotide binding
lipoamide binding
NAD binding
2-oxoglutarate metabolic process
acetyl-CoA biosynthetic process from pyruvate
aging
cell redox homeostasis
dihydrolipoamide metabolic process
gastrulation
lipoate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
regulation of membrane potential
sperm capacitation
Gene Ontology Biological Process:
2-oxoglutarate metabolic process
acetyl-CoA biosynthetic process from pyruvate
aging
cell redox homeostasis
dihydrolipoamide metabolic process
gastrulation
lipoate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
regulation of membrane potential
sperm capacitation
Gene Ontology Molecular Function:
dihydrolipoyl dehydrogenase activity
flavin adenine dinucleotide binding
lipoamide binding
NAD binding
Gene Ontology Cellular Component:
acrosomal matrix
cilium
mitochondrion
myelin sheath
nucleoplasm
oxoglutarate dehydrogenase complex
pyruvate dehydrogenase complex
Keywords:
FAD
Flavoprotein
NAD
Oxidoreductase
Pyruvate
Redox-active center

Publication

PubMed ID:
11181995