Names & Taxonomy
- Uniprot ID:
- A0A024R3S2
- Entry Name:
- A0A024R3S2_HUMAN
- Status:
- unreviewed
- Protein Names:
- Muscarinic acetylcholine receptor
- Gene Names:
- CHRM3 hCG_1641761
- Gene Names Orf:
- hCG_1641761
- Gene Names Primary:
- CHRM3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 590
- Sequence:
- MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
- Gene Ontology Go:
- asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
postsynaptic membrane
acetylcholine binding
drug binding
G-protein coupled acetylcholine receptor activity
positive regulation of smooth muscle contraction
regulation of vascular smooth muscle contraction
saliva secretion
smooth muscle contraction - Gene Ontology Biological Process:
- positive regulation of smooth muscle contraction
regulation of vascular smooth muscle contraction
saliva secretion
smooth muscle contraction - Gene Ontology Molecular Function:
- acetylcholine binding
drug binding
G-protein coupled acetylcholine receptor activity - Gene Ontology Cellular Component:
- asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
postsynaptic membrane - Keywords:
- Cell junction
Cell membrane
G-protein coupled receptor
Membrane
Postsynaptic cell membrane
Receptor
Synapse
Transducer
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 11181995