Names & Taxonomy
- Uniprot ID:
- A5X5Y0
- Entry Name:
- 5HT3E_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E)
- Gene Names:
- HTR3E
- Gene Names Primary:
- HTR3E
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
- Cross Reference Drug Bank:
- DB01049 DB00898
- Gene Ontology Go:
- integral component of membrane
plasma membrane
G-protein coupled serotonin receptor activity
serotonin-activated cation-selective channel activity
cation transmembrane transport
ion transmembrane transport
serotonin receptor signaling pathway
transmembrane transport - Gene Ontology Biological Process:
- cation transmembrane transport
ion transmembrane transport
serotonin receptor signaling pathway
transmembrane transport - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
serotonin-activated cation-selective channel activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P46098