Names & Taxonomy

Uniprot ID:
Q9UQF2
Entry Name:
JIP1_HUMAN
Status:
reviewed
Protein Names:
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene Names:
MAPK8IP1 IB1 JIP1 PRKM8IP
Gene Names Primary:
MAPK8IP1
Organism:
Homo sapiens (Human)

Structure

Length:
711
Sequence:
MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
Gene Ontology Go:
axonal growth cone
cell body
cytoplasm
cytosol
dendritic growth cone
dentate gyrus mossy fiber
endoplasmic reticulum membrane
mitochondrial membrane
nucleus
perinuclear region of cytoplasm
synapse
kinesin binding
MAP-kinase scaffold activity
protein kinase inhibitor activity
JUN phosphorylation
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of JUN kinase activity
regulation of JNK cascade
regulation of transcription, DNA-templated
vesicle-mediated transport
Gene Ontology Biological Process:
JUN phosphorylation
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of JUN kinase activity
regulation of JNK cascade
regulation of transcription, DNA-templated
vesicle-mediated transport
Gene Ontology Molecular Function:
kinesin binding
MAP-kinase scaffold activity
protein kinase inhibitor activity
Gene Ontology Cellular Component:
axonal growth cone
cell body
cytoplasm
cytosol
dendritic growth cone
dentate gyrus mossy fiber
endoplasmic reticulum membrane
mitochondrial membrane
nucleus
perinuclear region of cytoplasm
synapse
Keywords:
3D-structure
Complete proteome
Cytoplasm
Diabetes mellitus
Disease mutation
Endoplasmic reticulum
Membrane
Mitochondrion
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3 domain
Ubl conjugation
Interacts With:
P12023; P00533; P04626; O14733; O43318; P45983

Publication

PubMed ID:
9933567 10574993 11238452 11726277 11912189 12756254 11147798 14507925 12937412 16195223 17709393 18286207 10700186