Names & Taxonomy
- Uniprot ID:
- Q9NPF4
- Entry Name:
- OSGEP_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)
- Gene Names:
- OSGEP GCPL1
- Gene Names Primary:
- OSGEP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 335
- Sequence:
- MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
- Catalytic Activity:
- L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Gene Ontology Go:
- cytoplasm
nucleus
metal ion binding
N(6)-L-threonylcarbamoyladenine synthase
gene expression
tRNA modification
tRNA processing
tRNA threonylcarbamoyladenosine modification - Gene Ontology Biological Process:
- gene expression
tRNA modification
tRNA processing
tRNA threonylcarbamoyladenosine modification - Gene Ontology Molecular Function:
- metal ion binding
N(6)-L-threonylcarbamoyladenine synthase - Gene Ontology Cellular Component:
- cytoplasm
nucleus - Keywords:
- Acyltransferase
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Reference proteome
Transferase
tRNA processing