Names & Taxonomy
- Uniprot ID:
- Q9NPB9
- Entry Name:
- ACKR4_HUMAN
- Status:
- reviewed
- Protein Names:
- Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
- Gene Names:
- ACKR4 CCBP2 CCR11 CCRL1 VSHK1
- Gene Names Primary:
- ACKR4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Early endosome
Function
- Function:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
- Gene Ontology Go:
- early endosome
integral component of plasma membrane
plasma membrane
recycling endosome
chemokine receptor activity
scavenger receptor activity
chemokine-mediated signaling pathway
chemotaxis
G-protein coupled receptor signaling pathway
immune response - Gene Ontology Biological Process:
- chemokine-mediated signaling pathway
chemotaxis
G-protein coupled receptor signaling pathway
immune response - Gene Ontology Molecular Function:
- chemokine receptor activity
scavenger receptor activity - Gene Ontology Cellular Component:
- early endosome
integral component of plasma membrane
plasma membrane
recycling endosome - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix