Names & Taxonomy
- Uniprot ID:
- Q9H9S3
- Entry Name:
- S61A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)
- Gene Names:
- SEC61A2
- Gene Names Primary:
- SEC61A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
- Gene Ontology Go:
- cytosol
endoplasmic reticulum membrane
integral component of membrane
ribosome binding
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
protein transport - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
protein transport - Gene Ontology Molecular Function:
- ribosome binding
- Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
Protein transport
Reference proteome
Translocation
Transmembrane
Transmembrane helix
Transport