Names & Taxonomy
- Uniprot ID:
- Q9H2P9
- Entry Name:
- DPH5_HUMAN
- Status:
- reviewed
- Protein Names:
- Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)
- Gene Names:
- DPH5 AD-018 CGI-30 HSPC143 NPD015
- Gene Names Orf:
- AD-018 CGI-30 HSPC143 NPD015
- Gene Names Primary:
- DPH5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 285
- Sequence:
- MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
- Proteomes:
- UP000005640
Function
- Function:
- S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
- Pathway:
- Protein modification; peptidyl-diphthamide biosynthesis.
- Catalytic Activity:
- 4 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- = 4 S-adenosyl-L-homocysteine + diphthine methyl ester-.
- Gene Ontology Go:
- cytosol
diphthine synthase activity
cellular protein metabolic process
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
post-translational protein modification - Gene Ontology Biological Process:
- cellular protein metabolic process
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
post-translational protein modification - Gene Ontology Molecular Function:
- diphthine synthase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Alternative splicing
Complete proteome
Methyltransferase
Reference proteome
S-adenosyl-L-methionine
Transferase