Names & Taxonomy
- Uniprot ID:
- Q9GZV3
- Entry Name:
- SC5A7_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7)
- Gene Names:
- SLC5A7 CHT1
- Gene Names Primary:
- SLC5A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 580
- Sequence:
- MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- apical plasma membrane
axon
clathrin-coated endocytic vesicle
dendrite
early endosome
integral component of membrane
perikaryon
plasma membrane
plasma membrane raft
synaptic vesicle
choline binding
choline transmembrane transporter activity
choline:sodium symporter activity
acetylcholine biosynthetic process
neuromuscular synaptic transmission
neurotransmitter secretion
synaptic transmission
synaptic transmission, cholinergic
transmembrane transport - Gene Ontology Biological Process:
- acetylcholine biosynthetic process
neuromuscular synaptic transmission
neurotransmitter secretion
synaptic transmission
synaptic transmission, cholinergic
transmembrane transport - Gene Ontology Molecular Function:
- choline:sodium symporter activity
choline binding
choline transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
axon
clathrin-coated endocytic vesicle
dendrite
early endosome
integral component of membrane
perikaryon
plasma membrane
plasma membrane raft
synaptic vesicle - Keywords:
- Complete proteome
Glycoprotein
Ion transport
Membrane
Neurodegeneration
Neurotransmitter biosynthesis
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport