Names & Taxonomy
- Uniprot ID:
- Q9GZU7
- Entry Name:
- CTDS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)
- Gene Names:
- CTDSP1 NIF3 NLIIF SCP1
- Gene Names Primary:
- CTDSP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
- Catalytic Activity:
- -serine/threonine phosphate + H(2)O = -serine/threonine + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per monomer.;
- Enzyme Regulation:
- ENZYME REGULATION: Stimulated by GTF2F1. Inhibited by beryllofluoride anions.
- Active Site:
- ACT_SITE 96 96 4-aspartylphosphate intermediate.; ACT_SITE 98 98 Proton donor.
- Gene Ontology Go:
- extracellular exosome
nucleoplasm
nucleus
CTD phosphatase activity
metal ion binding
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of neuron differentiation
negative regulation of protein phosphorylation
protein dephosphorylation
regulation of transcription from RNA polymerase II promoter - Gene Ontology Biological Process:
- negative regulation of G1/S transition of mitotic cell cycle
negative regulation of neuron differentiation
negative regulation of protein phosphorylation
protein dephosphorylation
regulation of transcription from RNA polymerase II promoter - Gene Ontology Molecular Function:
- CTD phosphatase activity
metal ion binding - Gene Ontology Cellular Component:
- extracellular exosome
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Metal-binding
Nucleus
Polymorphism
Protein phosphatase
Reference proteome - Interacts With:
- Q99618; P58466; P02686