Names & Taxonomy
- Uniprot ID:
- Q99447
- Entry Name:
- PCY2_HUMAN
- Status:
- reviewed
- Protein Names:
- Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase)
- Gene Names:
- PCYT2
- Gene Names Primary:
- PCYT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 389
- Sequence:
- MIRNGRGAAGGAEQPGPGGRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF
- Proteomes:
- UP000005640
Function
- Function:
- Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.
- Pathway:
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
- Catalytic Activity:
- CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
- Cross Reference Drug Bank:
- DB00709
- Gene Ontology Go:
- endoplasmic reticulum membrane
ethanolamine-phosphate cytidylyltransferase activity
glycerophospholipid biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ethanolamine-phosphate cytidylyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Lipid biosynthesis
Lipid metabolism
Nucleotidyltransferase
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Transferase