Names & Taxonomy
- Uniprot ID:
- Q99437
- Entry Name:
- VATO_HUMAN
- Status:
- reviewed
- Protein Names:
- V-type proton ATPase 21 kDa proteolipid subunit (V-ATPase 21 kDa proteolipid subunit) (Vacuolar proton pump 21 kDa proteolipid subunit) (hATPL)
- Gene Names:
- ATP6V0B ATP6F
- Gene Names Primary:
- ATP6V0B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 205
- Sequence:
- MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Vacuole membrane; Multi-pass membrane protein.
Function
- Function:
- Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Gene Ontology Go:
- endosome membrane
integral component of membrane
phagocytic vesicle membrane
vacuolar proton-transporting V-type ATPase, V0 domain
proton-transporting ATPase activity, rotational mechanism
transporter activity
ATP hydrolysis coupled proton transport
cell redox homeostasis
cellular iron ion homeostasis
insulin receptor signaling pathway
ion transmembrane transport
proton transport
regulation of macroautophagy
transferrin transport
transmembrane transport
vacuolar acidification - Gene Ontology Biological Process:
- ATP hydrolysis coupled proton transport
cell redox homeostasis
cellular iron ion homeostasis
insulin receptor signaling pathway
ion transmembrane transport
proton transport
regulation of macroautophagy
transferrin transport
transmembrane transport
vacuolar acidification - Gene Ontology Molecular Function:
- proton-transporting ATPase activity, rotational mechanism
transporter activity - Gene Ontology Cellular Component:
- endosome membrane
integral component of membrane
phagocytic vesicle membrane
vacuolar proton-transporting V-type ATPase, V0 domain - Keywords:
- Alternative splicing
Complete proteome
Hydrogen ion transport
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Vacuole