Names & Taxonomy
- Uniprot ID:
- Q96AZ6
- Entry Name:
- ISG20_HUMAN
- Status:
- reviewed
- Protein Names:
- Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20)
- Gene Names:
- ISG20 HEM45
- Gene Names Primary:
- ISG20
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 181
- Sequence:
- MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
Function
- Function:
- Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
- Catalytic Activity:
- Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Gene Ontology Go:
- Cajal body
cytoplasm
nucleolus
nucleoplasm
nucleus
PML body
3'-5'-exoribonuclease activity
exonuclease activity
exoribonuclease II activity
metal ion binding
single-stranded DNA 3'-5' exodeoxyribonuclease activity
U1 snRNA binding
U2 snRNA binding
U3 snoRNA binding
cell proliferation
cytokine-mediated signaling pathway
defense response to virus
DNA catabolic process, exonucleolytic
negative regulation of viral genome replication
response to virus
RNA catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
rRNA processing
type I interferon signaling pathway - Gene Ontology Biological Process:
- cell proliferation
cytokine-mediated signaling pathway
defense response to virus
DNA catabolic process, exonucleolytic
negative regulation of viral genome replication
response to virus
RNA catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
rRNA processing
type I interferon signaling pathway - Gene Ontology Molecular Function:
- 3'-5'-exoribonuclease activity
exonuclease activity
exoribonuclease II activity
metal ion binding
single-stranded DNA 3'-5' exodeoxyribonuclease activity
U1 snRNA binding
U2 snRNA binding
U3 snoRNA binding - Gene Ontology Cellular Component:
- Cajal body
cytoplasm
nucleolus
nucleoplasm
nucleus
PML body - Keywords:
- 3D-structure
Alternative splicing
Antiviral defense
Complete proteome
Cytoplasm
Exonuclease
Hydrolase
Immunity
Innate immunity
Manganese
Metal-binding
Nuclease
Nucleus
RNA-binding
Reference proteome
rRNA processing