Names & Taxonomy
- Uniprot ID:
- Q92781
- Entry Name:
- RDH1_HUMAN
- Status:
- reviewed
- Protein Names:
- 11-cis retinol dehydrogenase (11-cis RDH) (11-cis RoDH) (EC 1.1.1.315) (9-cis retinol dehydrogenase) (9cRDH) (Retinol dehydrogenase 5) (Short chain dehydrogenase/reductase family 9C member 5)
- Gene Names:
- RDH5 HSD17B9 RDH1 SDR9C5
- Gene Names Primary:
- RDH5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 318
- Sequence:
- MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAVY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all-trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP.
- Pathway:
- Cofactor metabolism; retinol metabolism.
- Catalytic Activity:
- 11-cis-retinol- + NAD(+) = 11-cis-retinal- + NADH.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by 9-cis-, 13-cis- and all-trans-retinoic acids, with the most potent inhibitor being 13-cis-retinoic acid. Weakly inhibited by oleic acid.
- Active Site:
- ACT_SITE 175 175 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- cell body
endoplasmic reticulum lumen
endoplasmic reticulum membrane
retinol dehydrogenase activity
phototransduction, visible light
retinoid metabolic process
retinol metabolic process
visual perception - Gene Ontology Biological Process:
- phototransduction, visible light
retinoid metabolic process
retinol metabolic process
visual perception - Gene Ontology Molecular Function:
- retinol dehydrogenase activity
- Gene Ontology Cellular Component:
- cell body
endoplasmic reticulum lumen
endoplasmic reticulum membrane - Keywords:
- Complete proteome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Membrane
NAD
Oxidoreductase
Polymorphism
Reference proteome
Sensory transduction
Signal
Vision