Names & Taxonomy
- Uniprot ID:
- Q8TCT7
- Entry Name:
- SPP2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)
- Gene Names:
- SPPL2B IMP4 KIAA1532 PSL1
- Gene Names Primary:
- SPPL2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 592
- Sequence:
- MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
- Active Site:
- ACT_SITE 359 359
- Gene Ontology Go:
- actin cytoskeleton
centrosome
endosome membrane
Golgi-associated vesicle membrane
integral component of cytoplasmic side of endoplasmic reticulum membrane
integral component of lumenal side of endoplasmic reticulum membrane
lysosomal membrane
membrane
nucleoplasm
plasma membrane
aspartic endopeptidase activity, intramembrane cleaving
protein homodimerization activity
membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
membrane protein proteolysis
regulation of immune response - Gene Ontology Biological Process:
- membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
membrane protein proteolysis
regulation of immune response - Gene Ontology Molecular Function:
- aspartic endopeptidase activity, intramembrane cleaving
protein homodimerization activity - Gene Ontology Cellular Component:
- actin cytoskeleton
centrosome
endosome membrane
Golgi-associated vesicle membrane
integral component of cytoplasmic side of endoplasmic reticulum membrane
integral component of lumenal side of endoplasmic reticulum membrane
lysosomal membrane
membrane
nucleoplasm
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Endosome
Glycoprotein
Golgi apparatus
Hydrolase
Lysosome
Membrane
Polymorphism
Protease
Reference proteome
Signal
Transmembrane
Transmembrane helix