Names & Taxonomy
- Uniprot ID:
- Q8TCC7
- Entry Name:
- S22A8_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3)
- Gene Names:
- SLC22A8 OAT3
- Gene Names Primary:
- SLC22A8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 542
- Sequence:
- MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
- Cross Reference Drug Bank:
- DB00787 DB00718 DB00437 DB00345 DB00168 DB09060 DB00181 DB03793 DB01053 DB00887 DB01414 DB01140 DB00456 DB01326 DB01327 DB01329 DB00493 DB01212 DB00567 DB02659 DB01597 DB00501 DB00286 DB08912 DB00586 DB00390 DB01160 DB00917 DB00254 DB09272 DB00584 DB00783 DB00927 DB00695 DB01004 DB00536 DB01050 DB00328 DB01009 DB00583 DB00279 DB01583 DB01065 DB01033 DB00563 DB06710 DB01017 DB01051 DB00198 DB01092 DB00595 DB00812 DB00554 DB00175 DB01032 DB00908 DB00863 DB00936 DB06335 DB00139 DB00300 DB00469 DB00624 DB00759 DB00577 DB00313 DB00495
- Gene Ontology Go:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
inorganic anion exchanger activity
sodium-independent organic anion transmembrane transporter activity
anion transmembrane transport
response to toxic substance
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- anion transmembrane transport
response to toxic substance
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- inorganic anion exchanger activity
sodium-independent organic anion transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Detoxification
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport