Names & Taxonomy
- Uniprot ID:
- Q8NFA2
- Entry Name:
- NOXO1_HUMAN
- Status:
- reviewed
- Protein Names:
- NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)
- Gene Names:
- NOXO1 P41NOX SH3PXD5
- Gene Names Primary:
- NOXO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 376
- Sequence:
- MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 3: Cell membrane
Function
- Function:
- Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
- Cross Reference Drug Bank:
- DB05265
- Gene Ontology Go:
- intracellular
NADPH oxidase complex
plasma membrane
enzyme binding
identical protein binding
phosphatidylinositol binding
phospholipid binding
superoxide-generating NADPH oxidase activator activity
extracellular matrix disassembly
regulation of hydrogen peroxide metabolic process
regulation of respiratory burst
small GTPase mediated signal transduction
superoxide metabolic process - Gene Ontology Biological Process:
- extracellular matrix disassembly
regulation of hydrogen peroxide metabolic process
regulation of respiratory burst
small GTPase mediated signal transduction
superoxide metabolic process - Gene Ontology Molecular Function:
- enzyme binding
identical protein binding
phosphatidylinositol binding
phospholipid binding
superoxide-generating NADPH oxidase activator activity - Gene Ontology Cellular Component:
- intracellular
NADPH oxidase complex
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Lipid-binding
Membrane
Reference proteome
Repeat
SH3 domain - Interacts With:
- Itself; P13498; Q86UR1