Names & Taxonomy
- Uniprot ID:
- Q86Z14
- Entry Name:
- KLOTB_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
- Gene Names:
- KLB
- Gene Names Primary:
- KLB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1044
- Sequence:
- MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRVVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
- Gene Ontology Go:
- integral component of membrane
intracellular
plasma membrane
fibroblast growth factor binding
fibroblast growth factor receptor binding
hydrolase activity, hydrolyzing O-glycosyl compounds
activation of MAPKK activity
axon guidance
carbohydrate metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
carbohydrate metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- fibroblast growth factor binding
fibroblast growth factor receptor binding
hydrolase activity, hydrolyzing O-glycosyl compounds - Gene Ontology Cellular Component:
- integral component of membrane
intracellular
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix - Interacts With:
- Q9NSA1