Names & Taxonomy
- Uniprot ID:
- Q71RS6
- Entry Name:
- NCKX5_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5)
- Gene Names:
- SLC24A5 JSX NCKX5
- Gene Names Primary:
- SLC24A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 500
- Sequence:
- MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, trans-Golgi network membrane
Function
- Function:
- Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+).
- Gene Ontology Go:
- integral component of membrane
melanosome
trans-Golgi network
trans-Golgi network membrane
calcium channel activity
calcium ion binding
calcium, potassium:sodium antiporter activity
potassium ion binding
sodium ion binding
symporter activity
calcium ion transmembrane transport
cellular calcium ion homeostasis
ion transmembrane transport
ion transport
negative regulation of melanin biosynthetic process
response to stimulus
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- calcium ion transmembrane transport
cellular calcium ion homeostasis
ion transmembrane transport
ion transport
negative regulation of melanin biosynthetic process
response to stimulus
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- calcium, potassium:sodium antiporter activity
calcium channel activity
calcium ion binding
potassium ion binding
sodium ion binding
symporter activity - Gene Ontology Cellular Component:
- integral component of membrane
melanosome
trans-Golgi network
trans-Golgi network membrane - Keywords:
- Albinism
Alternative splicing
Antiport
Calcium
Calcium transport
Complete proteome
Golgi apparatus
Ion transport
Membrane
Polymorphism
Potassium
Potassium transport
Reference proteome
Sensory transduction
Signal
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport