Names & Taxonomy
- Uniprot ID:
- Q5XXA6
- Entry Name:
- ANO1_HUMAN
- Status:
- reviewed
- Protein Names:
- Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2)
- Gene Names:
- ANO1 DOG1 ORAOV2 TAOS2 TMEM16A
- Gene Names Primary:
- ANO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 986
- Sequence:
- MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
- Enzyme Regulation:
- ENZYME REGULATION: ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).
- Cross Reference Drug Bank:
- DB04941
- Gene Ontology Go:
- apical plasma membrane
chloride channel complex
cytoplasm
extracellular exosome
plasma membrane
calcium activated cation channel activity
chloride channel activity
intracellular calcium activated chloride channel activity
iodide transmembrane transporter activity
voltage-gated chloride channel activity
cation transmembrane transport
cation transport
cellular response to heat
chloride transmembrane transport
chloride transport
detection of temperature stimulus involved in sensory perception of pain
iodide transport
ion transmembrane transport
multicellular organism development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of anion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- cation transmembrane transport
cation transport
cellular response to heat
chloride transmembrane transport
chloride transport
detection of temperature stimulus involved in sensory perception of pain
iodide transport
ion transmembrane transport
multicellular organism development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of anion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- calcium activated cation channel activity
chloride channel activity
intracellular calcium activated chloride channel activity
iodide transmembrane transporter activity
voltage-gated chloride channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
chloride channel complex
cytoplasm
extracellular exosome
plasma membrane - Keywords:
- Alternative splicing
Calcium
Cell membrane
Chloride
Chloride channel
Complete proteome
Cytoplasm
Developmental protein
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport