Names & Taxonomy
- Uniprot ID:
- Q53H96
- Entry Name:
- P5CR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)
- Gene Names:
- PYCRL
- Gene Names Primary:
- PYCRL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 274
- Sequence:
- MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.
- Pathway:
- Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
- Catalytic Activity:
- L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.42 mM for NADH
- Enzyme Regulation:
- ENZYME REGULATION: Not inhibited by proline.
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- cytosol
pyrroline-5-carboxylate reductase activity
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-proline biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-proline biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- pyrroline-5-carboxylate reductase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Acetylation
Alternative splicing
Amino-acid biosynthesis
Complete proteome
Cytoplasm
NADP
Oxidoreductase
Polymorphism
Proline biosynthesis
Reference proteome - Interacts With:
- O00560