Names & Taxonomy

Uniprot ID:
Q16873
Entry Name:
LTC4S_HUMAN
Status:
reviewed
Protein Names:
Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Leukotriene-C(4) synthase)
Gene Names:
LTC4S
Gene Names Primary:
LTC4S
Organism:
Homo sapiens (Human)

Structure

Length:
150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Function

Function:
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
Catalytic Activity:
Leukotriene C(4) = leukotriene A(4) + glutathione.
Active Site:
ACT_SITE 31 31 Proton donor.
Cross Reference Drug Bank:
DB00143
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
nuclear envelope
nuclear outer membrane
enzyme activator activity
glutathione binding
glutathione peroxidase activity
glutathione transferase activity
leukotriene-C4 synthase activity
lipid binding
arachidonic acid metabolic process
cellular oxidant detoxification
cellular response to lipopolysaccharide
cellular response to vitamin A
leukotriene biosynthetic process
leukotriene metabolic process
lipoxin metabolic process
lipoxygenase pathway
response to axon injury
response to drug
response to inorganic substance
small molecule metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
cellular oxidant detoxification
cellular response to lipopolysaccharide
cellular response to vitamin A
leukotriene biosynthetic process
leukotriene metabolic process
lipoxin metabolic process
lipoxygenase pathway
response to axon injury
response to drug
response to inorganic substance
small molecule metabolic process
Gene Ontology Molecular Function:
enzyme activator activity
glutathione binding
glutathione peroxidase activity
glutathione transferase activity
leukotriene-C4 synthase activity
lipid binding
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
nuclear envelope
nuclear outer membrane
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Leukotriene biosynthesis
Lyase
Membrane
Nucleus
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8052639 7937884 8626689 8898379 15489334 8446623 7599836 7766706 9820300 10896305 12023288 19233132 17632548 17632546