Names & Taxonomy
- Uniprot ID:
- Q16850
- Entry Name:
- CP51A_HUMAN
- Status:
- reviewed
- Protein Names:
- Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)
- Gene Names:
- CYP51A1 CYP51
- Gene Names Primary:
- CYP51A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 503
- Sequence:
- MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
- Pathway:
- Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
- Catalytic Activity:
- A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00199 DB01167 DB01026 DB00916 DB01045 DB01153 DB01007
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
plasma membrane
heme binding
iron ion binding
sterol 14-demethylase activity
cholesterol biosynthetic process
cholesterol biosynthetic process via 24,25-dihydrolanosterol
demethylation
small molecule metabolic process
steroid biosynthetic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
cholesterol biosynthetic process via 24,25-dihydrolanosterol
demethylation
small molecule metabolic process
steroid biosynthetic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- heme binding
iron ion binding
sterol 14-demethylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Endoplasmic reticulum
Heme
Iron
Lipid biosynthesis
Lipid metabolism
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transmembrane
Transmembrane helix