Names & Taxonomy

Uniprot ID:
Q16827
Entry Name:
PTPRO_HUMAN
Status:
reviewed
Protein Names:
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)
Gene Names:
PTPRO GLEPP1 PTPU2
Gene Names Primary:
PTPRO
Organism:
Homo sapiens (Human)

Structure

Length:
1216
Sequence:
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNWEEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 1136 1136 Phosphocysteine intermediate.
Gene Ontology Go:
apical plasma membrane
axon
dendritic spine
extracellular exosome
growth cone
integral component of membrane
integral component of plasma membrane
lamellipodium
lateral plasma membrane
neuron projection
plasma membrane
phosphatase activity
protein homodimerization activity
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
Wnt-protein binding
axon guidance
cell morphogenesis
glomerular visceral epithelial cell differentiation
glomerulus development
lamellipodium assembly
monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
negative regulation of cell-substrate adhesion
negative regulation of glomerular filtration
negative regulation of neuron projection development
negative regulation of retinal ganglion cell axon guidance
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
regulation of glomerular filtration
slit diaphragm assembly
Gene Ontology Biological Process:
axon guidance
cell morphogenesis
glomerular visceral epithelial cell differentiation
glomerulus development
lamellipodium assembly
monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
negative regulation of cell-substrate adhesion
negative regulation of glomerular filtration
negative regulation of neuron projection development
negative regulation of retinal ganglion cell axon guidance
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
regulation of glomerular filtration
slit diaphragm assembly
Gene Ontology Molecular Function:
phosphatase activity
protein homodimerization activity
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
Wnt-protein binding
Gene Ontology Cellular Component:
apical plasma membrane
axon
dendritic spine
extracellular exosome
growth cone
integral component of membrane
integral component of plasma membrane
lamellipodium
lateral plasma membrane
neuron projection
plasma membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
P04626; Q02763

Publication

PubMed ID:
7753550 7665166 10498613 14702039 16541075 15489334 21722858 19167335 18058037