Names & Taxonomy

Uniprot ID:
Q16822
Entry Name:
PCKGM_HUMAN
Status:
reviewed
Protein Names:
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32)
Gene Names:
PCK2 PEPCK2
Gene Names Primary:
PCK2
Organism:
Homo sapiens (Human)

Structure

Length:
640
Sequence:
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVQLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Function:
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Pathway:
Carbohydrate biosynthesis; gluconeogenesis.
Catalytic Activity:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).
Cofactor:
COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Active Site:
ACT_SITE 306 306
Gene Ontology Go:
extracellular exosome
mitochondrial matrix
mitochondrion
GTP binding
metal ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
phosphoenolpyruvate carboxykinase activity
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
GTP binding
metal ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
phosphoenolpyruvate carboxykinase activity
Gene Ontology Cellular Component:
extracellular exosome
mitochondrial matrix
mitochondrion
Keywords:
Acetylation
Alternative splicing
Complete proteome
Decarboxylase
GTP-binding
Gluconeogenesis
Lyase
Manganese
Metal-binding
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Interacts With:
P84022

Publication

PubMed ID:
8645161 9657976 12508121 15489334 21269460 24275569 25944712