Names & Taxonomy

Uniprot ID:
Q16774
Entry Name:
KGUA_HUMAN
Status:
reviewed
Protein Names:
Guanylate kinase (EC 2.7.4.8) (GMP kinase)
Gene Names:
GUK1 GMK
Gene Names Primary:
GUK1
Organism:
Homo sapiens (Human)

Structure

Length:
197
Sequence:
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA
Proteomes:
UP000005640

Function

Function:
Essential for recycling GMP and indirectly, cGMP.
Catalytic Activity:
ATP + GMP = ADP + GDP.
Active Site:
ACT_SITE 44 44
Gene Ontology Go:
cytosol
ATP binding
guanylate kinase activity
ATP metabolic process
dATP metabolic process
dGDP biosynthetic process
dGMP metabolic process
drug metabolic process
GDP biosynthetic process
GDP-mannose metabolic process
glycoprotein transport
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
purine nucleotide metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
ATP metabolic process
dATP metabolic process
dGDP biosynthetic process
dGMP metabolic process
drug metabolic process
GDP biosynthetic process
GDP-mannose metabolic process
glycoprotein transport
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
purine nucleotide metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
ATP binding
guanylate kinase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Kinase
Nucleotide-binding
Reference proteome
Transferase

Publication

PubMed ID:
8647247 8663313 14702039 16710414 15489334 19413330 21269460 24275569 25944712