Names & Taxonomy

Uniprot ID:
Q16769
Entry Name:
QPCT_HUMAN
Status:
reviewed
Protein Names:
Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)
Gene Names:
QPCT
Gene Names Primary:
QPCT
Organism:
Homo sapiens (Human)

Structure

Length:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides -beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Catalytic Activity:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 201 201 Proton acceptor.
Gene Ontology Go:
extracellular exosome
glutaminyl-peptide cyclotransferase activity
zinc ion binding
cellular protein modification process
peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Gene Ontology Biological Process:
cellular protein modification process
peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Gene Ontology Molecular Function:
glutaminyl-peptide cyclotransferase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular exosome
Keywords:
3D-structure
Acyltransferase
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal
Transferase
Zinc

Publication

PubMed ID:
7999256 14702039 15815621 15489334 15063747 18486145 16135565 18072935 21671571 21288892